MO13-2 Predicting the Treatment Related Toxicity by Geriatric-8 Geriatric Assessment Screening Tool

By 2022, about one-fifth of Thai population will be age 65 or older. The aging population continues to grow at an unprecedented rate, which also a main of newly diagnosed cancer patient. Cancer therapy in older adult causing higher risk for treatment related toxicity. Geriatric8 (G8) screening tool are practical and easy assessed. Moreover, it can address the impairments and have the potential to predict risk of adverse event of cancer treatment. The purpose of the study is to evaluate the relationship between cancer treatment-related toxicity and G8 score. A retrospective cross sectional analysis of patients age equal or older than 65 years who received cancer treatment in Chonburi hospital, Thailand. Geriatric assessment by G8 screening tool. The adverse events were identified when equal or more than grading 2 after first cycle of treatment by Common Terminology Criteria for Adverse Events (CTCAE) Version 3.0. In total 126 patients with median (range) aged of 72 (65 - 92) years with Gastrointestinal (37%), Lung (36%), Genitourinary (10%), Hepatobiliary (6%), Breast (5%) and other (6%) cancer enrolled in this study. More than half of case were male (55.6%). ECOG Performance Status score is 0, 1 and 2 in 25.4%, 53.2% and 19.0% of patients, respectively. The median (range) G8 score was 12 (4 -17). Prevalence of fit group (G8 more than14) was 21%. Fit group had less grade 2 to 5 toxicity (25.9%) than vulnerable or frail group (43.4%) although it was not statistically significant (p = 0.0751). The average dose reduction of treatment was 12.2% in fit group, meanwhile 15.4% in vulnerable or frail group. The G8 screening tool showed a tendency of prediction properties for identifying elderly cancer patients who could have treatment related toxicity. However dose reduction rate of treatment influenced on the frequency of toxicity in our study.