PO-691-04 SATURATED FATTY ACIDS DIFFERENTIALLY MODULATE ION CHANNEL AND STRUCTURAL REMODELING IN MATURE IPSC-DERIVED ATRIAL CARDIOMYOCYTES LEADING TO OBESITY-INDUCED ATRIAL FIBRILLATION

Obesity-induced atrial fibrillation (AF) is modulated increased fatty infiltration in the atrial myocardium leading to increased exposure to free fatty acids (FFA). Mass spectrometry studies of obese mice have shown increased saturated FAs (SFA), monounsaturated FAs (MUFA), and polyunsaturated FAs (PUFA) compared to lean controls with the highest increase in the PUFA, linoleic acid. While some reports suggest that some SFAs and MUFAs induce ventricular arrhythmias in mice, the differential electrophysiological effects of SFAs, MUFAs, and PUFAs on the atria remain unclear.