Impact of Rabeprazole on APO-Dabigatran Exposure in Healthy Volunteers.
CJC open(2023)
摘要
When APO-dabigatran is administered with rabeprazole, the exposure to dabigatran is reduced by about 30%, which is similar to the level observed with Pradaxa when it was co-administered with a proton pump inhibitor. However, the finding that one-third of participants had a > 50% reduction in exposure is concerning, and it highlights the need for caution in patients who have, or are at risk of, reduced gastric acidity.
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关键词
rabeprazole,apo-dabigatran
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