Novel Insights into M6a Modification of Coding and Non-Coding RNAs in Tumor Biology: from Molecular Mechanisms to Therapeutic Significance

Accumulating evidence has revealed that m 6 A modification, the predominant RNA modification in eukaryotes, adds a novel layer of regulation to the gene expression.Dynamic and reversible m 6 A modification implements sophisticated and crucial functions in RNA metabolism, including generation, splicing, stability, and translation in messenger RNAs (mRNAs) and non-coding RNAs (ncRNAs).Furthermore, m 6 A modification plays a determining role in producing various m 6 A-labeling RNA outcomes, thereby affecting several functional processes, including tumorigenesis and progression.Herein, we highlighted current advances in m 6 A modification and the regulatory mechanisms underlying mRNAs and ncRNAs in distinct cancer stages.Meanwhile, we also focused on the therapeutic significance of m 6 A regulators in clinical cancer treatment.