LB880 Identifying common and disease-specific pathways through comparative scRNA-Seq profiling of four skin autoimmune diseases

Motivated by the observation that the risk of developing a second autoimmune disorder increases for patients that are afflicted by one condition and by the large number of shared genetic variants associated with diverse autoimmune diseases, we began a study to uncover both the shared and disease-specific markers of skin autoimmune disorders. Here we present a preliminary analysis of four conditions that differ drastically in their main type of autoimmune response. We collected skin samples from 10 controls and 39 individuals affected with vitiligo (Th1), psoriasis (Th17), dermatomyositis (Th1), and cutaneous lupus erythematosus (complex).