Deep tissue contractility sensing with biointegrated microlasers

Marcel Schubert,Lewis Woolfson,Isla M. R. Barnard,Amy M Dorward,Becky Casement,Soraya Caixeiro,Andrew Morton,Gavin B. Robertson,Paul L. Appleton,Gareth B. Miles,Carl S. Tucker,Samantha J. Pitt,Malte C. Gather

Biophotonics Congress 2021（2021）

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摘要

Characterizing single cell contractility in the beating heart is strongly limited by light scattering and extreme tissue dynamics. Here, we use tissue-integrated microlasers to measure contractility in live zebrafish and living myocardial slices at a depth several times deeper than multiphoton microscopy-based techniques.

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