Dampened Inflammation and Improved Survival After CXCL5 Administration in Murine Lupus via Myeloid and Neutrophil Pathways.

Xiubo Fan,Chin Teck Ng,Dianyang Guo,Frances Lim,Jia Chi Tan,Annie Law, Lim Hee Goh,Zhi Yong Poon,Alice Cheung,Say Li Kong,Michelle Tan,Shang Li,Alwin Loh,Anne James,Tony Lim,Jinmiao Chen,Julian Thumboo,William Hwang,Andrea Low

Arthritis & rheumatology (Hoboken, N.J.)（2023）

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摘要

We found that serum CXCL5 levels were significantly lower in SLE patients than in healthy individuals and were negatively correlated with disease activity. By administering CXCL5 intravenously in a mouse model of lupus, mouse survival improved, and indices of disease activity reduced significantly. Taken together, these findings indicate CXCL5 administration may represent a novel myeloid/neutrophil-targeting therapy for SLE.

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关键词

murine lupus,cxcl5 administration,inflammation,myeloid

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