HP-573-02 ASSOCIATION OF AGE WITH PROCEDURAL COMPLICATIONS AND IN-HOSPITAL OUTCOMES FROM LEFT ATRIAL APPENDAGE OCCLUSION DEVICE IMPLANTATION IN PATIENTS WITH ATRIAL FIBRILLATION

Age stratified analyses of atrial fibrillation (AF) patients undergoing percutaneous left atrial appendage occlusion (LAAO) are limited. To compare in-hospital outcomes in elderly AF patients (age > 80 years) to a relatively younger cohort (age ≤ 80 years) after LAAO using a national US database. Data were extracted from National Inpatient Sample for calendar years 2015-2018. LAAO device implantations were identified on the basis of International Classification of Diseases, 9th and 10th Revision, Clinical Modification codes of 37.90 and 02L73DK. The outcomes assessed in our study included complications, inpatient mortality and resource utilization with LAAO. A total of 36,065 LAAO recipients were included in the final analysis and approximately 35% (12,475) of such implantations occurred in elderly AF patients. Elderly AF patients had a higher prevalence of major complications (6.7% vs. 5.7%, p < 0.01) and mortality (0.4% vs. 0.1%, p < 0.01) after LAAO device implantation in the crude analysis. After multivariate adjustment of potential confounders, age > 80 years was associated with inpatient mortality (adjusted odds ratio [aOR] 4.439, 95% confidence interval [CI] 2.391-8.239) but not with major complications (aOR 1.084, 95% CI 0.971-1.211), prolonged length of stay (aOR 0.943, 95% CI 0.88-1.101) and increased hospitalization costs (aOR 0.909, 95% CI 0.865-0.955). A significant proportion of LAAO device implantations occurred in elderly AF patients. Advanced age was associated with inpatient mortality but did not predict other LAAO procedural related outcomes of major complications, prolonged length of stay and increased hospitalization costs.