Novel shikonin derivatives suppress cell proliferation, migration and induce apoptosis in human triple-negative breast cancer cells via regulating PDK1/PDHC axis

Qingqing Chen,Hongwei Han,Faxiang Lin,Liangjie Yang,Lu Feng,Xiaohui Lai,Zhongling Wen,Minkai Yang,Changyi Wang,Yudi Ma,Tongming Yin,Guihua Lu,Hongyan Lin,Jinliang Qi,Yonghua Yang

Life Sciences（2022）

引用 6|浏览18

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摘要

In conclusion, the novel SK derivatives E2 and E5 inhibited tumor glycolysis by targeting PDK1 and ultimately induced apoptosis. Our data demonstrated that E2 would be a good lead compound for the treatment of human TNBC as a novel PDK1 inhibitor.

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关键词

Aerobic glycolysis,Triple-negative breast cancer,Pyruvate dehydrogenase kinase,Shikonin,Molecular docking

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