Integrative Functional Genomics Identifies Systemic Lupus Erythematosus Causal Genetic Variant in the IRF5 Risk Locus.

Guojun Hou,Tian Zhou,Ning Xu,Zhihua Yin,Xinyi Zhu,Yutong Zhang,Yange Cui,Jianyang Ma,Yuanjia Tang,Zhaorui Cheng,Yiwei Shen,Yashuo Chen,Ling-Hua Zou,Yong-Fei Wang,Zihang Yin,Ya Guo,Huihua Ding,Zhizhong Ye,Nan Shen

Arthritis & rheumatology (Hoboken, N.J.)（2023）

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摘要

These results demonstrate that the rs4728142-A allele increases the SLE risk by affecting ZBTB3 binding, chromatin status, and regulating IRF5 expression, establishing a biologic link between genetic variation and lupus pathogenesis.

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risk locus

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