Transplantation of olfactory ensheathing cells decreases local and serological monocyte chemoattractant protein 1 level during the acute phase of rat spinal cord injury.

Yiqun Wang,Minjie Gong,Xijing He, Yutong Wu,Yuhuan Li,Jialiang Li,Zhijing Wen,Yibin Wang,Pengzhen Gu,Haopeng Li

Neuroreport（2022）

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摘要

Our study reports that transplantation of OECs promotes locomotor functional recovery after SCI and alleviates acute inflammation by decreasing local and serological MCP1 levels. We provide preliminary evidence that MCP1 might serve as a potential biomarker to reflect the severity of SCI, which is of great interest in future studies.

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关键词

spinal cord injury,olfactory ensheathing cell,cell transplantation,monocyte chemoattractant protein 1,inflammation,myeloid cells

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