Humoral and cellular immunity in patients with rare autoimmune rheumatic diseases following SARS-CoV-2 vaccination.

Leher Gumber,Nancy Gomez,Georgina Hopkins, Davis Tucis, Laura Bartlett,Kieran Ayling,Kavita Vedhara, Graham Steers,Mithun Chakravorty,Megan Rutter,Hannah Jackson, Patrick Tighe,Alastair Ferraro,Sheila Power,Marie-Josèphe Pradère,David Onion,Peter C Lanyon,Fiona A Pearce,Lucy Fairclough

Rheumatology (Oxford, England)（2022）

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摘要

Following two doses, most RAIRD patients have lower antibody levels than the lowest HC and lower anti-spike T cells. RAIRD patients with low/no antibodies have diminished numbers and poor quality of memory T cells which lack proliferative and functional capacities.

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关键词

SARS-CoV-2,T cells,antibody,cell mediated,rare autoimmune rheumatic diseases,vaccination

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