Genetic architecture underlying IgG-RF production is distinct from that of IgM-RF.

Ai Yaku,Yuki Ishikawa,Takeshi Iwasaki,Ryosuke Hiwa,Keitaro Matsuo,Hiroh Saji,Kimiko Yurugi,Yasuo Miura,Moritoshi Furu,Hiromu Ito,Takao Fujii,Taira Maekawa,Motomu Hashimoto,Koichiro Ohmura,Tsuneyo Mimori,Chikashi Terao

Rheumatology (Oxford, England)（2022）

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摘要

We found a unique genetic architecture of IgG-RF(-) RA, which showed a strong association with the SE allele less frequent among Japanese but the most frequent in Europeans. The findings could shed light on uncovered RA pathology.

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关键词

Autoantigens and Autoantibodies,Biomarkers,Epidemiology,Genetics,Immunogenetics and HLA,Major histocompatibility complex,Rheumatoid Arthritis,Statistics

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