Combined Utility of p16 and BRAF V600E in the Evaluation of Spitzoid Tumors: Superiority to PRAME and Correlation with FISH

John L. McAfee, Richard Scarborough,Xuefei Sophia Jia,Elizabeth M. Azzato,Caroline Astbury,Shira Ronen,Aleodor A. Andea,Steven D. Billings,Jennifer S. Ko

Journal of Cutaneous Pathology（2022）

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摘要

p16/BRAF V600E IHC predicts FISH results. "Low-risk" lesions (p16 /BRAF V600E ) uncommonly have meaningful FISH abnormalities (11%). PRAME may have limited utility in this setting.

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关键词

BRAF,FISH,PRAME,Spitz,malignant,p16

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