Diastereoselective Synthesis of Chromenopyrrole Derivative Enabled by Multicomponent Reaction of Isocyanide, Allenoate, and Phenol

We report here an isocyanide-based multicomponent reaction to assemble a number of tricyclic chromenopyrrole derivatives with diastereoselectivity. Mechanistically, this protocol employs phenol as electron-rich species, thus following bicyclization process to approach a series of diverse structures.