Hypersensitivity to heparins- cases report

Introductions: Heparins are widely used as an anticoagulants in clini-cal practice. They can provoke all types of hypersensitivity reactions, although most common are delayed hypersensitivity reactions. Imme-diate type hypersensitivity reactions to heparin are very rare and there are only a few cases described. In this paper four cases of heparin hypersensitivity were described. Clinical manifestation, allergological work-up and further individual therapeutic recommendations were di-scussed. Moreover general diagnostic and therapeutic management in the case of heparin hypersensitivity was given.