Interleukin-6 blockers improve inflammation-induced lipid metabolism impairments but induce liver fibrosis in collagen-induced arthritis.

Tshimangadzo M Denga,Sulè Gunter,Serena Fourie,Regina le Roux,Ashmeetha Manilall,Aletta M E Millen,Lebogang Mokotedi

Endocrine, metabolic & immune disorders drug targets（2022）

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摘要

IL-6 blockers ameliorated inflammation-induced lipid metabolism impairments, however they induced liver fibrosis. Although IL-6 blockers may reduce inflammation-induced metabolic impairments in chronic inflammatory disorders, routine monitoring of liver function is warranted while on treatment.

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关键词

IL-6 receptor blocker,collagen-induced arthritis,inflammation,lipid metabolism,liver fibrosis

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