Levels of Interleukine-6 and Interleukin -18 in Iraqi Women with Polycystic Ovarian Syndrome Infected with Urinary Tract Infections

Background: Women with the polycystic ovarian syndrome (PCOS) are among the most common sufferers of endocrine abnormalities, so Urinary tract infections were the most prevalent sickness for women worldwide, Elevated levels of interleukins are presumably part of the pathogenesis of this clinical manifestation, for this reason, this study intends to examine the levels of interleukin-6 and interleukin-18 in PCOS Iraqi women who have been diagnosed with UTIs. Patients and Methods: 159 blood and urine specimens were collected from Iraqi women visiting Al Yarmouk teaching hospital in Baghdad with the control group. The urine specimen was cultured on MacConkey and blood agar, and interleitkin (IL-6 and IL-18) levels were measured using the ELIZA technique. Results: Results current showed no significant variance (P>0.05) mean of age between PCOS with and without UTI, and UTI patients were (24.94 +/- 4.14, 25.84 +/- 4.89, 27.00 +/- 2.12) respectively compared to control (28.70 +/- 7.88). According to BMI, a non-significant difference was noticed between the studied groups, so level of IL-6 in the study groups(PCOS with and without UTI ) ( 8.93 +/- 10.29; 19.35 +/- 5.08 pg/mL) was more than UTI group ( 7.36 +/- 5.52) pg/mL, as well as levels of IL-18 in (PCOS with and without ITT' ) (9.36 +/- 2.18; 9.27 +/- 1.47 pg/mL) more than UTI (8.58 +/- 1.28 pg/mL), and control (5.30 +/- 0.49 pg/mL).the current study showed levels of IL-6 were increased significantly (p<0.01) in women infected with UTIs caused by E. coli (20.0580 +/- 14.85921), Klebsiella pneumoniae (16.4148 +/- 5.31959), Staphylococcus aureus (19.2518 +/- 7.04125), Pseudomonas aeurogenosa (16.9500 +/- 2.75482). respectively. Conclusion: No significant variance for age and BMI between PCOS with UTI and without UTI, and UTI patients, So both (IL-6 & IL-18) levels in groups (PCOS with and without UTT) were more than UTI group.