Metal-organic-framework-involved nanobiocatalysis for biomedical applications

Substantial efforts have been devoted to closing the gap between the fragility of biocatalysts and their practical applications. Metal-organic frameworks (MOFs) with operational stability, high loading capacity, and precisely tailored structure have been extensively studied in nanobiocatalysis to interact with biocatalysts, further tuning the catalytic efficiency and biological functions of biocatalysts. Furthermore, atomic- level catalytic centers and customizable coordination microenvironments allow MOFs to be the alternatives for biocatalysts, further realizing biomimetic catalysis and expanding the application scenarios. Herein, this review focuses on several intelligent strategies for MOFs as carriers to modulate the activity of biocatalysts, as well as the fine design and regulation of MOFs as biomimetic catalysts to improve enzyme-mimetic catalytic activity and selectivity. Various potential biomedical applications, including cancer therapies, anti-bacteria, antioxidant treatment, and biosensing will be briefly depicted. Finally, the challenging issues and opportunities for the future exploration of MOF-involved biocatalysts will be discussed.