Elevated serum human epididymis protein 4 is associated with disease severity and worse survival in idiopathic pulmonary fibrosis: a cohort study.

Mi Tian,Kaifang Meng,Yujuan Gao,Ji Zhang,Miaomiao Xie,Yaqiong Tian,Xiaoqin Liu,Miao Ma,Ying Cai,Hongyan Wu,Jingjing Ding,Jingyu Chen,Hourong Cai

Annals of translational medicine（2022）

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摘要

The expression of serum HE4 was obviously elevated in IPF patients, especially in AE-IPF patients. In addition, serum HE4 could be utilized as a biomarker of disease severity and poor prognosis of IPF patients. These findings warrant further validation in larger, multi-center, and longitudinal cohorts.

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关键词

Idiopathic pulmonary fibrosis (IPF),acute exacerbation (AE),gender-age-physiology index (GAP index),human epididymis protein 4 (HE4)

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