Programmed Death-Ligand 1 Expression in Lung Cancer and Paired Brain Metastases—a Single-Center Study in 190 Patients

Alexandra Kündig,Philipp Zens,Christian Fung,Amina Scherz,Ferdinando Cerciello,Evelyn Herrmann,Ekin Ermis,Ralph A Schmid,Erik Vassella,Sabina Berezowska

JTO Clinical and Research Reports（2022）

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摘要

PD-L1 expression was mostly concordant between primary lung carcinoma and its BM and between resections of BM and stereotactic biopsies, mirrored by tissue microarray cores. Differences in PD-L1 TPS existed primarily in cases with TPS greater than 10%, for which also human assessment tends to be most error prone.

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关键词

Brain metastasis,Lung cancer,NSCLC,PD-L1,Immune checkpoint inhibitors

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