Variant APOL1 protein in plasma associates with larger particles in humans and mouse models of kidney injury.

Michael Andrews,Teruhiko Yoshida,Clark M Henderson,Hannah Pflaum, Ayako McGregor,Joshua A Lieberman,Ian H de Boer,Tomas Vaisar,Jonathan Himmelfarb,Bryan Kestenbaum,Joon-Yong Chung,Stephen M Hewitt,Briana A Santo,Brandon Ginley,Pinaki Sarder,Avi Z Rosenberg,Taichi Murakami,Jeffrey B Kopp,Zsuzsanna Kuklenyik,Andrew N Hoofnagle

PloS one（2022）

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摘要

These results suggest that plasma APOL1 is dynamic and contributes to the progression of kidney disease in humans, which may have implications for treatment of APOL1-associated kidney disease and for kidney transplantation.

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