The mechanism of VCP-mediated metastasis of osteosarcoma based on cell autophagy and the EMT pathway.

An An Li,Yu Zhang,Fan Li,Yang Zhou,Zhi Li Liu,Xin Hua Long

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico（2023）

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摘要

VCP is likely to promote the migration and invasion of OS cells by inducing EMT, possibly via TGF-β1/smad2/3 signaling pathway. In this process, VCP-mediated autophagy may contribute to successful distant metastasis of tumor cells indirectly.

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关键词

Autophagy,Epithelial–mesenchymal transition (EMT),Metastasis,Osteosarcoma,Valosin-containing protein (VCP)

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