Polyphyllin VII as a Potential Drug for Targeting Stemness in Hepatocellular Cancer via STAT3 Signaling.

Liuhang Xu, Ziqi Chen, Yangbin Wang,Yulin Li,Zhongyu Wang, Fangzhou Li,Xueyan Xi

Current cancer drug targets（2023）

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摘要

PP7 can effectively suppress tumor initiation, growth, and metastasis and inhibit stemness through regulation of STAT3 signaling pathway in liver cancer cells. Our data would add more evidence to further clarify the therapeutic effect of PP7 against HCC.

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关键词

CD133,OCT-4,PP7,STAT3 signaling,cancer stem cells,hepatocellular carcinoma

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