A phase 2, open‐label, randomized, multiple dose study evaluating Inarigivir in treatment‐naïve patients with chronic hepatitis B

Man‐Fung Yuen,C. Y. Chen,C. J. Liu,W. J. Jeng,M. Elkhashab,C. S. Coffin,W. Kim, S. Greenbloom, A. Ramji,Y. S. Lim,Yoon Jun Kim,Scott K. Fung,D. J. Kim,Jeong Won Jang,K. S. Lee,R. P. Iyer, C. Macfarlane,K. Jackson,S. Locarnini,H. L. Y. Chan,N. H. Afdhal

Liver International（2022）

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摘要

Twelve-week Inarigivir up to 200 mg dose was associated with a reduction of HBV DNA, HBV RNA and antigen levels. A trend for greater HBsAg reduction was observed in Inarigivir pre-treated patients after switching to tenofovir.

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关键词

HBV DNA suppression,HBsAg level,Inarigivir,retinoic acid-inducible gene 1,tenofovir

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