MAGEA11 as a STAD Prognostic Biomarker Associated with Immune Infiltration.

Expression of MAGE family member A11 () is upregulated in different tumors. However, in gastric cancer, the prognostic significance of and its relationship with immune infiltration remain largely unknown. The expression of in pan-cancer and the receiver operating characteristic (ROC) and survival impact of gastric cancer were evaluated by The Cancer Genome Atlas (TCGA). Whether was an independent risk factor was assessed by Cox analysis. Nomograms were constructed from and clinical variables. Gene functional pathway enrichment was obtained based on differential analysis. The relationship between and immune infiltration was determined by the Tumor Immunity Estimation Resource (TIMER) and the Tumor Immune System Interaction Database (TISIDB). Finally, -sensitive drugs were predicted based on the CellMiner database. The results showed that the expression of mRNA in gastric cancer tissues was significantly higher than that in normal tissues. The ROC curve indicated an AUC value of 0.667. Survival analysis showed that patients with high had poor prognosis (HR = 1.43, = 0.034). In correlation analysis, mRNA expression was found to be associated with tumor purity and immune invasion. Finally, drug sensitivity analysis found that the expression of was correlated with seven drugs. Our study found that upregulated in gastric cancer was significantly associated with lower survival and invasion by immune infiltration. It is suggested that may be a potential biomarker and immunotherapy target for gastric cancer.