Dysfunctional Cortical Gradient Topography in Treatment-Resistant Major Depressive Disorder.

Lorenzo Pasquini,Susanna L. Fryer,Stuart J. Eisendrath,Zindel V. Segal,Alex J. Lee,Jesse A. Brown,Manish Saggar,Daniel H. Mathalon

Biological psychiatry. Cognitive neuroscience and neuroimaging（2022）

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摘要

Our findings provide preliminary support for widespread alterations in cortical gradient architecture in TRD, implicating a significant role for transmodal and limbic networks in mediating depression, anxiety, and lower mindfulness in patients with TRD.

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关键词

Connectivity gradients,Default mode network,Functional connectivity,Graph theory,Treatment-resistant major depressive disorder

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