Ligelizumab impairs IgE‐binding to plasmacytoid dendritic cells more potently than omalizumab and restores IFN‐α production and FOXP3 ⁺ Treg generation

Cristina Benito‐Villalvilla,Andrés de la Rocha‐Muñoz,Jacobo López‐Abente,Alexander Eggel,Iván Bottoli,Thomas Severin, Maximilian Woisetschläger,Oscar Palomares

Allergy（2022）

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摘要

The uncovered novel molecular mechanisms of ligelizumab to regulate functional properties of pDCs from atopic donors might have important clinical implications for anti-IgE treatments in different IgE-mediated diseases.

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关键词

IgE,T cells,allergy treament,basic immunology,dendritic cells

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Ligelizumab impairs IgE‐binding to plasmacytoid dendritic cells more potently than omalizumab and restores IFN‐α production and FOXP3 + Treg generation

Ligelizumab impairs IgE‐binding to plasmacytoid dendritic cells more potently than omalizumab and restores IFN‐α production and FOXP3 ⁺ Treg generation