Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19.

Daniela Matuozzo,Estelle Talouarn, Astrid Marchal,Jeremy Manry,Yoann Seeleuthner,Yu Zhang,Alexandre Bolze,Matthieu Chaldebas,Baptiste Milisavljevic,Peng Zhang,Adrian Gervais,Paul Bastard,Takaki Asano,Lucy Bizien,Federica Barzaghi,Hassan Abolhassani,Ahmad Abou Tayoun,Alessandro Aiuti,Ilad Alavi Darazam,Luis M Allende,Rebeca Alonso-Arias,Andrés Augusto Arias,Gokhan Aytekin,Peter Bergman,Simone Bondesan,Yenan T Bryceson,Ingrid G Bustos,Oscar Cabrera-Marante,Sheila Carcel,Paola Carrera,Giorgio Casari,Khalil Chaïbi,Roger Colobran,Antonio Condino-Neto,Laura E Covill,Loubna El Zein,Carlos Flores,Peter K Gregersen,Marta Gut,Filomeen Haerynck,Rabih Halwani,Selda Hancerli,Lennart Hammarström,Nevin Hatipoğlu,Adem Karbuz,Sevgi Keles,Christèle Kyheng,Rafael Leon-Lopez,Jose Luis Franco,Davood Mansouri,Javier Martinez-Picado,Ozge Metin Akcan,Isabelle Migeotte,Pierre-Emmanuel Morange,Guillaume Morelle,Andrea Martin-Nalda,Giuseppe Novelli,Antonio Novelli,Tayfun Ozcelik,Figen Palabiyik,Qiang Pan-Hammarström,Rebeca Pérez de Diego,Laura Planas-Serra,Daniel E Pleguezuelo,Carolina Prando,Aurora Pujol,Luis Felipe Reyes,Jacques G Rivière,Carlos Rodriguez-Gallego,Julian Rojas,Patrizia Rovere-Querini,Agatha Schlüter,Mohammad Shahrooei,Ali Sobh,Pere Soler-Palacin,Yacine Tandjaoui-Lambiotte,Imran Tipu,Cristina Tresoldi,Jesus Troya,Diederik van de Beek,Mayana Zatz,Pawel Zawadzki,Saleh Zaid Al-Muhsen,Hagit Baris-Feldman,Manish J Butte,Stefan N Constantinescu,Megan A Cooper,Clifton L Dalgard,Jacques Fellay,James R Heath,Yu-Lung Lau,Richard P Lifton,Tom Maniatis,Trine H Mogensen,Horst von Bernuth, Alban Lermine,Michel Vidaud,Anne Boland,Jean-François Deleuze,Robert Nussbaum,Amanda Kahn-Kirby,France Mentre, Sarah Tubiana,Guy Gorochov,Florence Tubach, Pierre Hausfater,Isabelle Meyts,Shen-Ying Zhang,Anne Puel,Luigi D Notarangelo,Stephanie Boisson-Dupuis, Helen C Su,Bertrand Boisson, Emmanuelle Jouanguy,Jean-Laurent Casanova,Qian Zhang,Laurent Abel,Aurélie Cobat

medRxiv : the preprint server for health sciences（2022）

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摘要

Rare variants of TLR3- and TLR7-dependent type I IFN immunity genes can underlie life-threatening COVID-19, particularly with recessive inheritance, in patients under 60 years old.

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