Huangqin Qingre Qubi Capsule inhibits RA pathology by binding FZD8 and further inhibiting the activity of Wnt/β-catenin signaling pathway

FZD8 expression was significantly up-regulated in AA rats and RA FLS. FZD8 significantly activated Wnt/β-catenin signaling pathway, promoted FLS abnormal proliferation, increased the levels of inflammatory factors IL-1β, IL-6 and IL-8, and significantly increased the expression of MMP3 and fibronectin. HQC has obvious therapeutic effect on AA rats. Combining molecular docking and molecular dynamics studies, we confirmed that HQC inhibited Wnt/β-catenin signaling pathway and RA pathology by binding FZD8.Image 1