Single nucleotide polymorphisms (rs3736228 and rs4988321) in low-density lipoprotein receptor-related protein-5 gene with predisposition to rheumatoid arthritis

•The study first time reported a significant association of LRP5 single nucleotide polymorphisms (SNPs) rs3736228 in the Pakistani population (Karachi).•The study first time reported the significant association of LRP5 single nucleotide polymorphisms (SNPs) rs4988321.•The study serves as baseline data for the development of biomarkers for early diagnosis of rheumatoid arthritis and the precision medicine approach.