Association between Rab31/ rs9965664 polymorphism and immunoglobulin therapy resistance in patients with Kawasaki disease.

Hongyan Yu,Yueling Lin,Yufen Xu,Kaining Chen,Yishuai Wang,Lanyan Fu,Huazhong Zhou,Lei Pi,Di Che,Xiantao Qiu,Xiaoqiong Gu

Frontiers in cardiovascular medicine（2022）

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摘要

These results suggested that rs9965664 polymorphism might be associated with an increased risk of IVIG resistance in southern Chinese patients with KD. The possible mechanism is that regulates the NLRP3 pathway negatively to inhibit IVIG response.

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关键词

IVIG resistance,Kawasaki disease,Rab31/rs9965664,intravenous immunoglobulin,polymorphism

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