The development and validation of sensitive LC-MS/MS method for quantitative bioanalysis of carmofur in mouse plasma and its application to pharmacokinetic study

Mohammad Mohiminul Islam,Ethan F Kub,Vilashini Rajaratnam,Shama P Mirza

Journal of Chromatography B（2022）

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摘要

•A sensitive, reliable, and accurate LC-MS/MS method was developed for analyzing carmofur in mouse plasma.•The developed method was applied to a pharmacokinetic study in mice.•This is the first report of an LC-MS/MS method for bioanalysis of carmofur.

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关键词

Carmofur,HCFU,Pharmacokinetics,LC-MS/MS,Mouse plasma

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