Interstitial Collagen Loss, Myocardial Remodeling, and Function in Primary Mitral Regurgitation

Mustafa I. Ahmed,Efstathia Andrikopoulou,Jingyi Zheng, Elena Ulasova,Betty Pat,Eric E. Kelley,Pamela Cox Powell,Thomas S. Denney,Clifton Lewis,James E. Davies,Victor Darley-Usmar,Louis J. Dell’Italia

JACC: Basic to Translational Science（2022）

引用 5|浏览19

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摘要

•The stretch of volume overload in PMR initiates interstitial collagen loss and decrease in LV sphericity index.•LV chamber diastolic function is normal whereas LA function, LV twist/volume slope, early LV untwist, and myocardial circumferential strain are impaired.•There is increased oxidative stress in the cardiomyocyte with cytoskeletal breakdown and myofibrillar loss in PMR.

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关键词

cardiac magnetic resonance,collagen loss,left ventricular remodeling,primary mitral regurgitation

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