Analysis of incidence data in developmental toxicity studies: Statistical tests to account for litter effects in fetal defect data.

Shawn F Harris,Sandra J McBride, Marjolein V Smith,Helen C Cunny,Keith R Shockley

Birth defects research（2023）

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摘要

The mRSCA test developed here compares favorably with other litter-based approaches and is robust across a range of background defect rates and litter size distributions, making it a practical choice for prenatal developmental toxicology studies involving both common and rare fetal defects.

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关键词

Rao-Scott Cochran-Armitage test,correlated binary data,fetal defect studies,litter effects,prenatal developmental toxicology,rodents,statistical models

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