NAMPT induces Mitochondrial and Barrier Dysfunction in Pulmonary Endothelial Cells

The focus in this presentation is the formulation of a general treatment of energy deposition applicable to target excitation by both fast and slow projectiles, including the dissipative dynamics of a non-equilibrium medium by means of a reduced statistical density operator treatment, which can be implemented computationally to provide measurable properties. The treatment combines two formalisms to provide a general theory of energy deposition in a target which interacts with a surrounding medium. The first formalism involves expressing inelastic collision cross sections in terms of time-correlation functions of scattering operators, usually given in the literature for a medium at thermal equilibrium. It is used to derive expressions for fast electronic excitation of the target, and for slow multicenter scattering by target ions. The second formalism introduces a reduced statistical density operator dependent only on variables of a primary region of interest, and accounting for fluctuation and dissipation phenomena arising from interactions of the target with its medium, or secondary region. The combined treatment leads to energy deposition rates corrected to include a term for disturbance by the projectile of the target original equilibrium, and a term accounting for dissipation phenomena in the target.