Pold4 is dispensable for mouse development, DNA replication and DNA repair

Xueping Gu,Qinjin Dai,Peng Du, Ning Li, Jiahui Li, Simiao Zeng,Shuyi Peng,Shengjun Tang,Lei Wang,Zhongcheng Zhou

Gene（2023）

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摘要

•Pold4 knockout mice are viable and there are no obvious negative effects on prenatal development.•Pold4 is dispensable for DNA replication.•Pold4 is dispensable for DNA repair.•Pold4 knockout mice decreased liver tumor incidence and exhibited an extended lifespan.

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关键词

Pold4,DNA replication,DNA damage,DNA repair,CRISPR

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