Seropositivity-Dependent Association between LINE-1 Methylation and Response to Methotrexate Therapy in Early Rheumatoid Arthritis Patients.

Amin Ravaei,Lia Pulsatelli,Elisa Assirelli,Riccardo Meliconi,Jacopo Ciaffi,Elisa Gremese,Barbara Tolusso,Carlo Salvarani,Marcello Govoni,Michele Rubini

Genes（2022）

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摘要

The LINE-1 methylation level in PBMCs of naïve ERA cases associates with the degree of response to MTX therapy in an opposite way depending on the presence of RF and ACPA antibodies. Our results suggest LINE-1 methylation level as a new epigenetic biomarker for predicting the degree of response to MTX in both double-positive and seronegative ERA patients.

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关键词

DNA methylation,LINE-1,anti-citrullinated protein antibody,biomarkers,methotrexate,pharmacoepigenetics,rheumatoid arthritis,rheumatoid factor

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