Two Co(II) Coordination Polymers: Crystal Structures and Treatment Activity on Brain Injury Combined with Ratanasampil (RNSP)

Two new Co(II)-containing coordination polymers, as known as {[Co(L)(H2O)(2)]center dot 2H(2)O}n (1) and {[Co(L)(H2O)(2)]center dot 1.5 H2O}(n )(2) have been obtained by reaction of the metal salt Co(NO3)(2)center dot 6H(2)O with the T-shaped ligand (4-3'-pyridyl-,6-4'-carboxylphenyl)picolinic acid (H2L) in the solvothermal reaction environments. Their therapeutic modalities against the local brain injury combined with rnsp were evaluated. First of all, the content of the inflammatory cytokines released into the cerebrospinal fluid after the added compound combined with RNSP was detected with ELISA assay. Moreover, the activity of JAK/STAT3 signaling pathway was evaluated by real time RT-PCR.