RNA-seq and ATAC-seq analysis of CD163 + macrophage-induced progestin-insensitive endometrial cancer cells.

Lulu Wang,Qiaoying Lv,Pengfei Wu,Shuhan Luo, Sijia Liu,Xiaojun Chen,Xuezhen Luo

Cancer medicine（2023）

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摘要

We identified CD163 macrophages as an important mediator of progestin desensitization and an unfavorable factor for the efficacy of fertility-preserving treatment in AEH/EEC patients.

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关键词

CD163+ macrophages,endometrial cancer,extracellular matrix,progesterone receptor,progestin insensitivity

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