Inhibition of signaling downstream of beta-2 adrenoceptor by propranolol in prostate cancer cells.

Aljoharah Alaskar,Amaal Abdulraqeb Ali,Sazzad Hassan, Zakia Shinwari,Ayodele Alaiya,Urs von Holzen,Lance Miller,George Kulik

The Prostate（2023）

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摘要

The analysis of pS133CREB and pS157VASP allows measuring activation of PKA signaling downstream of beta-2 adrenoreceptors. Presented results on the ratio of propranolol/epinephrine and the time needed to inhibit signaling downstream of beta-2 adrenoreceptors will help to design clinical studies that examine the effects of propranolol on prostate tumors.

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关键词

PKA,beta-2 adrenoreceptors,epinephrine,propranolol,prostate cancer,stress

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