Amplified cancer immunotherapy of PD-L1 blockade by sequential tumor microenvironment reshaping and DC maturation

Peng Hua,Di Jiang,Zhaopei Guo,Huayu Tian,Xuesi Chen,Meiwan Chen

Chemical Engineering Journal（2023）

引用 2|浏览27

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摘要

•A two-step sequential delivery strategy was proposed to amplify anti-PD-L1 immunotherapy.•QB NPs reshaped tumor microenvironment to promote T cell infiltration and nanoparticle penetration.•CDFP NPs induced dendritic cell maturation and PD-L1 downregulation.•The immune cocktail therapy triggered potent antitumor immunity.

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关键词

PD-L1,CpG,Quercetin,Small hairpin RNA,Gene carrier,Immunotherapy

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