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A Noncoding Germline Variant Creates a Gain-of-Function De Novo Enhancer That up-Regulates IL5 Transcription to Cause Familial Hypereosinophilia, Revealing a Previously Undescribed Mechanism for Human Disease

Jung-Hyun Kim,Abbie Bowman, Senbagavalli Babu,Jan Cools,Sofie Demeyer,Majid Kazemian,Warren Leonard,Jian-Xin Lin,Michelle Makiya, Mathieu Perez,Colin L. Sweeney,Luis M. Franco,Neelam Redekar,Justin Lack,Linda Resar,Amy D. Klion

Blood（2022）

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