Pharmacogenetic variability and the probability of site of action target attainment during tuberculosis meningitis treatment: A physiologically based pharmacokinetic modeling and simulations study

Krina Mehta,Navaneeth Narayanan,Scott K Heysell,Gregory P Bisson,Selvakumar Subbian,Natalia Kurepina,Barry N Kreiswirth,Christopher Vinnard

Tuberculosis（2022）

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摘要

In this study, the combined effects of pharmacogenetic and M. tuberculosis MIC variability were potent determinants of target attainment in CNS. The potential for genotype-guided dosing during TBM treatment should be further explored in prospective clinical studies.

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关键词

pharmacokinetic modeling,tuberculosis meningitis treatment,pharmacogenetic variability

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