Mapping glioma heterogeneity using multiparametric F-18-choline PET/MRI in childhood and teenage-young adults

ObjectiveThe heterogeneity of post-treatment imaging remains a significant challenge in children and teenagers/young adults (TYA) diagnosed with glioma. The aim of this study was to evaluate the utility of F-18-choline PET/MRI in determining intratumoural heterogeneity in paediatric and TYA gliomas. MethodsTwenty-six patients (mean age 16 years, range 8-22 years) with suspected glioma disease progression were evaluated with F-18-choline PET/MRI. Relative cerebral blood volume (rCBV), apparent diffusion coefficient (ADC) and maximum standardised uptake values (SUVmax) in enhancing (enh) and non-enhancing (ne) tumour volumes and normal-appearing white matter (wm) were calculated (rCBV(enh), rCBV(ne), rCBV(wm), ADC(enh), ADC(ne), ADC(wm), SUVenh, SUVne and SUVwm). ResultsSignificantly higher SUVenh and SUVne compared with SUVwm were observed [SUVenh 0.89 (0.23-1.90), SUVne 0.36 (0.16-0.78) versus SUVwm 0.15 (0.04-1.19); P < 0.001 and P = 0.004, respectively]. Equivalent results were observed for ADV and rCBV (ADC(enh), ADC(ne): P < 0.001 versus ADC(wm); rCBV(enh), rCBV(ne): P < 0.001 versus rCBV(wm)). The highest values for mean SUVmax [0.89 (0.23-1.90)] and mean rCBV [2.1 (0.74-5.08)] were in the enhancing component, while the highest values for ADC [1780 mm(2)/s (863-2811)] were in the necrotic component. Conclusion(18)F-choline PET/MRI is able map imaging heterogeneity in paediatric and TYA gliomas, detecting post-treatment enhancing, non-enhancing, and necrotic tumour components equivalent to ADC and DSC-derived rCBV. This offers potential in the response assessment of diffuse non-enhancing gliomas and in selected cases such as posterior fossa tumours where quantitative MRI is technically difficult.