Histopathological Features of Cancer-Associated Venous Thromboembolism: Presence of Intrathrombus Cancer Cells and Prothrombotic Factors.

Toshihiro Gi,Aya Kuwahara,Atsushi Yamashita,Shuntaro Matsuda,Kazunari Maekawa,Sayaka Moriguchi-Goto,Yuichiro Sato,Yujiro Asada

Arteriosclerosis, thrombosis, and vascular biology（2023）

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摘要

Vascular wall invasion or cancer cell clusters in thrombi might influence thrombogenesis of cancer-associated VTE. TF and podoplanin in cancer cells and in monocyte/macrophages may induce coagulation reactions and platelet aggregation. Neutrophil extracellular traps may play a role in the early stages of VTE, regardless of cancer status.

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carcinoma,extracellular traps,fibrin,pathology,platelet aggregation,tissue factor,venous thromboembolism

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