Glucocorticoid in Combination with a TNF- Inhibitor: Treatment of Deep Vein Thrombosis in a Patient with Behcet's Disease

A 38-year-old man with deep vein thrombosis associated with Behcet's disease (BD) was admitted to our hospital due to worsening symptoms despite the initiation of direct oral anticoagulants (DOACs). Administration of oral prednisolone and an intravenous anti-tumor necrosis factor-alpha (TNF-& alpha;) monoclonal antibody dramatically improved his symptoms. In addition, he was incidentally diagnosed with autosomal dominant polycystic kidney disease, which increases the risk of aortic aneurysms. BD also increases the risk of aortic aneurysms. This case suggests that immunosuppressive treatment is effective in patients with inflammationrelated DOAC-refractory venous thrombosis who also suffer from BD.