White matter microstructure and sleep-wake disturbances in individuals at ultra-high risk of psychosis.

Jesper Ø Rasmussen,Dorte Nordholm,Louise B Glenthøj,Marie A Jensen,Anne H Garde,Jayachandra M Ragahava,Poul J Jennum,Birte Y Glenthøj,Merete Nordentoft,Lone Baandrup,Bjørn H Ebdrup,Tina D Kristensen

Frontiers in human neuroscience（2022）

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摘要

Compromised callosal microstructure in UHR individuals was related to objectively observed disruptions in sleep-wake functioning. Lower FA in ventrally located regions was associated with subjectively measured sleep-wake disturbances and was partly explained by psychopathology. These findings call for further investigation of sleep disturbances as a potential treatment target.

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关键词

diffusion weighted imaging,psychopathology,sleep,substance use,ultra-high risk of psychosis,white matter

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