Phase I study of a novel glioblastoma radiation therapy schedule exploiting cell-state plasticity.

Jamie A Dean,Shyam K Tanguturi,Daniel Cagney,Kee-Young Shin,Gilbert Youssef,Ayal Aizer,Rifaquat Rahman,Lubna Hammoudeh,David Reardon,Eudocia Lee,Jorg Dietrich,Kaoru Tamura,Masaru Aoyagi, Lacey Wickersham,Patrick Y Wen,Paul Catalano,Daphne Haas-Kogan,Brian M Alexander,Franziska Michor

Neuro-oncology（2022）

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摘要

A novel radiation therapy schedule based on mathematical modeling of cell-state plasticity is feasible and safe to administer to glioblastoma patients.

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关键词

cell-state plasticity,clinical trial,glioblastoma,mathematical modeling,radiation oncology

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