Engineering functional 3-dimensional patient-derived endocrine organoids for broad multiplatform applications

Naira Baregamian,Konjeti R Sekhar,Evan S Krystofiak,Maria Vinogradova,Giju Thomas,Emmanuel Mannoh,Carmen C Solórzano,Colleen M Kiernan,Anita Mahadevan-Jansen, Naji Abumrad,Michael L Freeman,Vivian L Weiss,Jeffrey C Rathmell,W Kimryn Rathmell

Surgery（2023）

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摘要

Our novel engineered endocrine patient-derived organoid models of thyroid, parathyroid and adrenal neoplasms represent an exciting and elegant alternative to current limited 2-dimensional systems and afford future broad multiplatform in vitro and translational applications, including in endocrine oncoimmunology.

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